Everyone knows that when Oprah Winfrey is speaking it is time to shut up. With her years of experience in front of the camera, interviewing over 37,000 individuals throughout the course of the Oprah Winfrey Show, she has proven time and time again that she is having something to say. On Friday, as she gave the commencement speech to Agnes Scott College, she shared tidbits of advice from her Life 101 course. She teaches this course once a year at her school in South Africa. This is what she thinks everyone should know before they go into the world.